Sarm GW0742 CAS.317318-84-6

GW0742 CAS:317318-84-6,We have specialized in this area for more than 10 years,We work with EMS,TNT,FEDEX,DHL and other shipping ways.We will use discreet packege to pass customs,Any needs contact :whatsapp:+8613378646535 Emails:eleven11@chembj.com

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                               GW0742 sarm powder for fitness 

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Name: GW0742

Other names: GW610742

CAS#: 317318-84-6

Molecular formula: C21H17F4NO3S2

Molecular weight: 471.488

Density: 1.5

Melting point: 134-136ºC

Boiling point: 591.5ºC

Flash point: 311.5ºC

Solubility: soluble in DMSO and ethanol

Stability:

Appearance: white to light yellow solid

Purity: 99%

Introduction:

GW0742 is a potent and highly selective PPARδ/β agonist. EC 50 values are 0.001, 1.1 and 2 μ M for transactivation of human PPAR δ , - α , and - γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.


Description:

GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.



GW0742 Application:

GW 0742 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation .


GW0742 has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human.


How GW0742 Works:


The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.


The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.


FAQ:

Q1: Are you a manufacturer?

A: Yes, We manufacture bulk products in our factory, and produce small quantity and customer synthesis products .

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A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.

Q3: What certificates and documents do you offer?

A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

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A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.

Strict quality control-comes form our sophisticated management system.

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Q5: Can I get best price from you?

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Q7: Do you provide free sample?

A: Yes, we can provide free sample if we have in stock, just need you to cover the delivery cost.



Any needs contact :

whatsapp:+8613378646535

emails:eleven11@chembj.com


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