GW0742 CAS.317318-84-6

GW0742, also known as GW610742, is a PPAR agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.

Product Details

Top Quality GW0742 Sarms Raw Powder

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Quick Details

GW0742, also known as GW610742, is a PPAR agonist. GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons. GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity. GW0742 has direct protective effects on right heart hypertrophy.

Quick Detail:

Product Name

GW0742

Synonym

GW-0742; GW610742

CAS

317318-84-6

EINECS

259-415-2

Assay

99%

Appearance

crystalline solid

Packing

1kg net/foil bag, 5kg/drum.

Standard

Enterprise Standard

Storage

Shading , Confined Preservation

Usage

A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.

Molecular Fomular

C21H17F4NO3S2

Molecular Weight

471.49

gw0742(3)


Application

GW0742 is a high affinity agonist reduces lung inflammation induced by bleomycin instillation in mice.


A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator


These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR).


Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.


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4. High quality service

Our goods packing will not contain any hormone information and can be sent out from different areas of china.At present,the goods customs clearance rate we send to United states and Europe is 99%,As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs.We also have completely re-send policy to some areas.


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