GW-501516 is a unique medication officially classified as a PPAR receptor agonist (PPAR-RA). Research for this medication began in 1992 in a conjoined effort between GlaxoSmithKline (GSK) and Ligand Pharmaceuticals. Research into this product was set forth in an effort to provide treatment for various cardiovascular diseases, as well as diabetes, obesity and other conditions. It was soon discovered that the PPAR-RA was highly effective at enhancing endurance, but it was also shown to carry a high potential cost. It was discovered that GW-501516 increased the chances of cancer significantly, and as a result, GSK dropped all further research. However, the studies that produced cancerous results used doses of GW-501516 that were 500 to even 1000 times the amount that a human being would take. If cancer is a risk with standard dosing is unknown.
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GW501516 (also known as GW-501,516, GW1516, GSK-516 and Endurobol)is a PPAR receptor. It activates the same pathways activated through exercise, including PPAR and AMP-activated protein kinase. It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone.
GW501516(Cardarine) Athletic Use
Endurance athletes may increase exercise endurance by stacking this PPAR with the AMP analog drug AICAR, or run cardarine solo. As a result, they will have a greater ability to reach higher RPM's during their runs without hitting the maximum heart rate. Regarding the bodybuilders, cardarine can benefit them in two ways: 1. Its ability to burn fat 2. Its ability to help the athlete have harder and longer workouts, without getting winded.
GW501516(Cardarine) Fat Loss
In terms of obesity, cardarine reverses metabolic abnormalities in obese and pre-diabetic men by stimulating fatty acid oxidation. That is, it burns fat by increasing glucose uptake in skeletal muscle tissue, which changes the body's metabolism to burn fat for energy instead of muscle or carbs. Incredibly, it does all this without dropping blood sugar levels like diabetic drugs do. Interestingly, when mice were given a high fat diet, they still lost fat, which proves that cardarine prevents obesity.
1. Endurance: It is recommended stacking cardarine with AICAR and/or Equipoise. This is the ultimate endurance stack that will turn you into a race horse.
2. Fat loss: The best shredder stack would be stacking cardarine with S4 (Andarine). This is a well known potent 'cutting' stack.
4. During PCT (post cycle therapy) or bridge: Since cardarine is not hormonal, it is in no way suppressive. Hence, you should not be scared of using it to keep fat off and improve your workouts between cycles during your bridge and PCT.
5. SARMs triple stack: If you want to recomp, cardarine stacks beautifully with S4 and MK-2866.
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