Estriol CAS.50-27-1

Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor.

Product Details

Estrogen Hormone Estriol CAS50-27-1 For Female Health

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Estriol Quick Details

Estriol can be a weak or strong estrogen depending on if it is given acutely or chronically when given to immature animals, but is an antagonist when given in combination with estradiol.Estriol may play a role in the development of breast cancer, but based on in vitro research, does appear to act as an antagonist to the G-protein coupled estrogen receptor.

Product Name






Molecular Weight





1.255 g/cm3

Melting Point

280-282 °C(lit.)

Boiling Point

469 °C at 760 mmHg

lash Point

220.8 °C


White crystalline powder




as per relevent regulations


pharmaceutical intermediates

Estriol Application:

1) Used for treating cervicitis, especially suitable for treating menopausal syndrome and senile vaginitis.
2) Used as the adjuvant drug for middle-term labor induction and artificial abortion.
3) Used for treating prostatic hypertrophy and prostate cancer.
4) In addition, it still has a rapid role in increasing the peripheral leukocytes.
5) It has efficacy in treating leukopenia caused by chemotherapy or radiotherapy as well as reducing the vascular permeability and fragility and can be used for the treatment of various kinds of hemorrhage.
6) It also has quick hemostasis effect on menorrhagia, hysterectomy or tonsillectomy.


How to Dose Estriol

The typical oral dose used in Western Europe is 2 to 5 mg daily, but because much of it is "dumped" by

the liver immediately, this may only ultimately amount to ½ to 1 mg of estriol actually getting into the body.

Many clinicians use an estriol cream that delivers 2 to 5 mg. When made as a cream, the pharmacist

should indicate on the container how much cream it takes to provide the 2 to 5 mg of estriol.

When you deliver estriol to your body via a cream, it is delivered in a much steadier fashion, whereas given orally it is subject to all the variables of how the digestive system and the liver are working from hour to


An estriol cream that delivers 0.5 mg, used every other day, has been shown to be very effective for treating vaginal atrophy and urinary tract infections. Published studies show that 0.5 mg estriol delivered every other day for 2 weeks, is adequate for most women, and this is how estriol is used by most women in


The reason that estriol is used only every other day is because it doesn't clear from the body as fast as the other estrogens and therefore one dose will last for two days. Using it every day can result in excessively high levels. Although estriol does not absorb through the skin as rapidly as estradiol or estrone, studies have shown that topical delivery of estriol is about twenty times more efficient than oral delivery.

Estriol Specification:





White to practically white, odorless, crystalline powder.

white crystalline powder, odorless




Melting point




Insoluble in water; sparingly soluble in alcohol; soluble in acetone, n ether, and in vegetable oils


Completeness of solution

The solution is clear and free from undissolved solid.


Loss on drying



Specific optical rotation

+54°~ +62°


Total impurities



Residue on ignition





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