Estradiol Cypionate CAS:313-06-4 Raw Powder
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Keywords: Estradiol Cypionate; Depofemin; Depo-Estradiol; CAS:313-06-4
1. Product Introduction
Product name:Estradiol Cypionate
Density:1.15g / cm3
Boiling point:532.8 ° C at 760 mmHg
Flash Point: 207.7 ° C
Vapor Pressure:5.73E-12mmHg at 25 ° C
Specification: USP/BPAppearance: White crystalline powder
2. Product description:Estradiol cypionate (brand name Depo-Estradiol, many others), orestradiol cipionate, also known as estradiol 17-cyclopentylpropionate or estradiol 17-cyclopentanepropionate, is a synthetic,steroidal estrogen and an estrogen ester - specifically, the 17-cypionate(cyclopentylpropionate) ester of estradiol - which is marketed in the United States, Canada,Europe, and throughout much of the rest of the world. It acts as a prodrug of estradiol, and hence, is considered to be anatural, bioidentical form of estrogen. Along with estradiol valerate, estradiol cypionate is one of the most widely used esters of estradiol.
3. Estradiol Cypionate COA
|Description||: White or Almost White Crystalline Powder||white powder|
|Specific Rotation||: +101°~+105°||+102.6°|
|Loss On Drying||: 1.0%max||0.27%|
|Melting Point||: 153~157ºC||153.0~155.0ºC|
|Organic Volatile Impurities||: meets the requirement.||Conforms|
|Related Substances||: meets the requirement.||Conforms|
|Residual Solvents||: meets the requirement.||Conforms|
|Particle Size||: 100% ¡Ü 20 microns||Conforms|
|Conclusion||The specification conform with USP30 standard|
4. Estradiol Cypionate Applications:
After hemostasis, the dosage was gradually reduced to 1mg/d. After 21 days of discontinuation, the estradiol injection was started on the 14th day, 10mg/day.The artificial menstrual cycle starts from the 5th day of bleeding with intramuscular injection of 1mg every day, and starts from the 16th day of injection with intramuscular injection of 10mg progesterone every day. After the two drugs are used up at the same time, the course of treatment will be repeated on the 5th day of the next bleeding, generally 2 to 3 cycles are needed.
Use the minimum effective dose and shorten the time as much as possible to reduce the possible adverse reactions;After hysterectomy, patients in both male and female patients are usually treated with cycle therapy, that is, drug administration for three weeks and drug withdrawal for one week, which is equivalent to the change of estrogen in the natural menstrual cycle. For women with uterus, progesterone can be added to the last 10-14 days of the cycle to avoid excessive stimulation, and the hormone concentration in the natural cycle can be simulated.Long-term or heavy use of estrogen, when drug withdrawal or reduction must be gradually reduced.
Long-term estrogen users should be regularly checked: blood pressure;Liver function;Exfoliated vaginal cells;Physical examination once every 6 to 12 months or as directed by the doctor;Cervical cancer curettes are administered once a year.For external use only.Postmenopausal women once 2.5g, in the morning or evening after the bath application.Use daily from 1st to 24th day of each month.Starting from the 13th day, the combination of oral progesterone preparation (e.g., angertan 100mg/ day) and the combination of 12 days.At the end of 25 solstice per month, the treatment was stopped for 1 week and the above treatment was repeated.Premenopausal women on the 6th day of the menstrual cycle, 2.5g daily, as above method applied to the skin, for 25 days, after 13 days plus progesterone preparation (such as angertan 100mg daily).
Apply to the skin of the arm, shoulder, neck, face, abdomen or thigh for 2min before dressing.Do not apply to breast and vaginal parts and do not touch mucous membranes.The product is absorbed through the skin and its estradiol/estrone ratio <1, which conforms to the physiological ratio and is effective in preventing osteoporosis.
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6. Order Process: