Ursodeoxycholic acid is white powder,almost insoluble in water,freely soluble in alcohol
Ursodeoxycholic acid (UDCA), also known as ursodiol, is a compound produced from bile by the action of intestinal bacteria. Since this bile acid is not produced directly by the body, it is known as a secondary bile acid.One of the functions of bile acids is to act in the intestine to help digest fats and fatsoluble vitamins from food. Ursodeoxycholic acid has been used in pharmacology to dissolve gallstones made of cholesterol, and to treat liver disorders. It has been used for a long time in both human and veterinary medicine.
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Ursodeoxycholic Acid ( UDCA ) CAS No. 128-13-2 Synonyms ( 3alpha; , 7beta; -Dihydroxy-5beta; -cholan-24-oic acid ) Assay(titration ): 98.5% min Related substance(TLC): Lithocholic acid: ≤ 0.1% Cholic acid: ≤ 0.5% CDCA: ≤ 1.0% Appearance: White powder, taste bitter, without stink Melting spot: 200 ° C ~ 204° C Specific optical rotation: +59 ° ~+62 ° Moisture: NMT 1.0 % Blazing residue: NMT 0.2 % Heavy metal: NMT 20ppm Loss on drying: NMT 1.0% Solubility: Very slightly soluble in water. Freely soluble in alcohol, Slightly soluble in cetone and in methylene chloride Shelf life: 2 years Package: 25kg/drum Function: Use of ursodeoxycholic acid in patients with liver disease, reduces cholesterol absorption and dissolve gallstones.
UDCA Powder Ursodeoxycholic Acid Can increase the secretion of bile acid. UDCA Powder Ursodeoxycholic Acid Reduce cholesterol in bile and cholesterol ester. UDCA Powder Ursodeoxycholic Acid Is conducive to the cholesterol gradually dissolve gallstones.
UDCA Powder Ursodeoxycholic Acid Should not be used for surgical treatment of cholesterol stone, but cannot dissolve the bile pigment stone, mixing and opaque X line of stones.
Usage: Used as an anticholelithogenic . Epimer with Chenodiol with respect to the hydroxyl group at C7 Gallstone dissolving drugs. Mainly used in the treatment of inoperable cholesterol gallstones, especially basic gallbladder function properly, stones 15mm or less in diameter, through X-ray, non-calcified cholesterol stones floating high cure rate. Of toxic hepatitis, cholecystitis, primary sclerosing cholangitis, primary biliary cirrhosis of liver also have some therapeutic effect. Improve the efficacy of treatment of chronic hepatitis C. Diarrhea, constipation rare, allergic reactions, itching, headache, dizziness, stomach pain, pancreatitis, and bradycardia. Biliary complete obstruction and severe liver dysfunction and pregnant women hanged.
White or almost white powder
Soluble in alcohol, Acetone, Methylene chloride
IR, TLC and Chrominance test
Specific Optical Rotation
Loss on drying
Secondary butyl alcohol ≤0.5%
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