Pharmaceutical Trifluoperazine Dihydrochloride CAS 440-17-5
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Product Name: Trifluoperazine Dihydrochloride
Melting point:243 °C (dec.)(lit.)
Chemical Properties:Cream Fine Powder
Trifluoperazine Dihydrochloride is a cell-permeable phenothiazine compound with antiadrenergic effects. Trifluoperazine is described as an antagonist of adrenergic receptors, demonstrating much higher activity at the α-1 over the α-2 adrenergic receptor. Trifluoperazine is also described to produce antidopaminergic effects. Trifluoperazine facilitates agonist induced elevation of cytosolic calcium at low concentrations (10μM), and antagonizes CaM (calmodulin) at higher concentrations. Potent and irreversible inhibitor of cAMP-gated cationic channels. Inhibits DNA repair. Potent neurotoxin. Trifluoperazine is an inhibitor of D2DR.
Trifluoperazine is an effective antipsychotic for people with schizophrenia. There is low-quality evidence that trifluoperazine increases the chance of being improved when compared to placebo when people are followed up for 19 weeks. There is low-quality evidence that trifluoperazine reduces the risk of relapse when compared with placebo when people are followed for 5 months.As of 2014 there was no good evidence for a difference between trifluoperazine and placebo with respect to the risk of experiencing intensified symptoms over a 16-week period nor in reducing significant agitation or distress.
There is no good evidence that trifluoperazine is more effective for schizophrenia than lower-potency antipsychotics like chlorpromazine, chlorprothixene, thioridazine and levomepromazine, but trifluoperazine appears to cause more adverse effects than these drugs.
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