Pramipexole/Mirapex/CAS: 191217-81-9

Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).

Product Details


1.Product Introduction

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2.Specifications:


Product name: Pramipexole

Purity:99%

 

CAS: 104632-26-0

 

Molecular formula: C10H17N3S

 

Molecular weight: 247.788

 

Appearance: white powder

 

Synonyms: Pramipexol; (-)-Pramipexole; 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-; Mirapexin; Oprymea; Pramipexol [Spanish]; Pramipexole Teva; Pramipexolum; Pramipexolum [Latin]; SUD919CL2Y; Sifrol; U-98528E; UNII-83619PEU5T; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole; 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, (S)-; (S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole




3.Applications:


Functions: Pramipexole dihydrochloride  is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease (PD) andrestless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some users of the selective serotonin reuptake inhibitor (SSRI) antidepressants. Pramipexole has shown robust effects on pilot studies in a placebo-controlled proof of concept study in bipolar disorder. It is also being investigated for the treatment of clinical depression and fibromyalgia.




4.prodection details


Test Items

Standard

Test Results

Character

Off-white to White  Crystalline powder

Off-White Crystalline powder

Solubility

Soluble in Water and Methanol, slightly soluble in Ethanol (96%), 

Almost insoluble in  Dichloromethane

Complies

 

Identification

(1)Specific Rotation -67~-69.5°(on anhydrate basis)

(2)IR: Meets the requirement.

(3) Optical purity Test

(4)Chloride Reaction

-68.8

 

Complies

Complies

Complies

Clarity

Clear, not deeper than Y6.

Complies

PH

2.8~3.4

3.15

Related Substances

Impurity A≤0.15%

Impurity B≤0.15%

Impurity C≤0.15%

Unknown single impurity≤0.1%

Total Impurity≤0.5%

Not detected

0.04%

Not detected

0.05%

0.16%

Impurity D

Impurity D≤0. 5%

0.1%

Water

4.5%~6.5%

4.9%

Heavy metals

≤10ppm

Complies

Sulfate Ash

≤0.1%

0.05%

Assay (on anhydrate basis)

99.0%~101.0%

99.8%



5. Packaging & Deliveryraw_fat_loss_powders_lorcaserin_hydrochloride_hemihydrate_

 

Package : 100g/bag,or at customer's requirements

Storage: Store in a cool, dry place and keep away from direct strong light.

Shelf Life :2 years



 



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