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Pimobendan Basic Info
|Alias||pimobendane, tradenames Vetmedin, Acardi, Heartmedin|
|PHYSICAL STATE||white crystalline powder|
|Usage||a cardiotonic agent. antiviral|
|Storage||Store in cool and dry places, keep away from strong light|
|Package methods||hundreds of disgusied pacakges|
|After-sales service||Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.|
|Shipping method||FedEx,UPS,DHL,EMS, Fedex and so on, by air or sea.Will choose the best shipping way.|
|Delivery time||delivery quickly at the day when receive the payment, will be deliveried in 4-7days after tracking|
|Payment Methods||Western union, money gram, bitcoin and bank transfer|
Pimobendan is a calcium sensitizer and a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilatoreffects.
Pimobendan cardiotonic agent. A study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by blocking phosphodiesterase III and potassium channel. Pimobendan's potent venodilating action makes it an appropriate treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.
Pimobendan sensitizes and increases the binding efficiency of cardiac troponin in the myofibril to the calcium ions that are already present in systole. In normal hearts it increases the consumption of oxygen and energy to the same degree as dobutamine but in diseased hearts it may not.
Pimobendan also causes peripheral vasodilation by inhibiting the function of phosphodiesterase III. This results in decreased resistance to blood flow through systemic arterioles, which decreases afterload (decreases the failing heart's workload) and reduces the amount of mitral regurgitation.
|Description||White or slightly yellowish powder||White or slightly yellowish powder|
|IR Indentification||The infrared absorption spectrum is concordant with the reference spectrum of standard||Conform|
|Melting point||About 242℃||244℃|
|Solubility||Practically insoluble in water, freely soluble in dimethylformamide, slightly solulbe in acetone and in methanol||Conform|
|Solvent Residue||Ethanol ≤2000ppm||300ppm|
|Particle size||98% pass through ASTM 40#screem||100%|
Single impurity A: ≤0.1%
Single impurity B: ≤0.1%
Other impurity: ≤0.1%
Total impurities: ≤0.2%
|Conclusion||Meet the requirements of EP6.0|