Pharmaceutical Metadoxine powder CAS:74536-44-0
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Another Name:5-oxo-L-proline, compound with 5-hydroxy-6-methylpyridine-3,4-
Chemical Properties Off-White Powder
Usage :Used for treating patients for liver functional disorders in performing stomatologic interventions and in treatment of acute and chronic alcoholism .
Treatment for acute alcohol intoxication
In animal studies, metadoxine increased the activity of acetaldehyde dehydrogenase enzyme, prevented the decrease in alcohol dehydrogenase activity in chronic ethanol-fed rats, accelerated plasma and urinary clearance of ethanol, inhibited the increase of fatty acid esters in the liver of ethanol-treated rats, prevented the formation of fatty liver in rats exposed to a dose of ethanol sufficient to induce fatty liver, increased glutathione levels in the hepatocytes of acutely and chronically alcohol-intoxicated rats, prevented glutathione depletion, lipid peroxidation damage, collagen deposition, and TNF-α secretions induced by alcohol and acetaldehyde in hepatocytes and hepatic stellate cells.
Treatment for liver disease:
Metadoxine may block the differentiation step of preadipocytes by inhibiting CREB phosphorylation and binding to the cAMP response element, thereby repressing CCAAT/enhancer-binding protein b during hormone-induced adipogenesis.Metadoxine, when given in an immediate release form in doses from 300 mg twice a day to 500 mg three times a day of up to 3 months, has been shown to improve biochemical indices of liver function as well as reduce ultrasonic evidence of fatty liver disease.
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Store in cool and dry area and keep away from direct sunlight.oC
2 years, keep in formal storage condition.
We accept any Qty you require, grams to kilograms.
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Delivery Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc.
Shipment Time:Within 12 hours after confirmation of your payment
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