Pharmaceutical Levamisole Hydrochloride for Anthelmintic
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Product name: Levamisole
CAS: 16595-80-5
EINECS: 240-654-6
Purity:98%
Appearance: white powder
Melting point: 226-231ºC
Solubility: 210G/L(20ºC)
MF: C11H12N2S.HCl
MW: 240.75
Levamisole Hydrochloride, is an anthelmintic agent commonly used in large livestock such as cattle, pigs and sheep. In 1971 it was found to have immunostimulatory properties and investigation into its use in humans began to expand.
Description:
Levamisole Hydrochloride CAS 16595-80-5 is an anthelmintic (animals roundworm, hookworm, etc.) agent commonly used in large livestock such as cattle, pigs and sheep. It can selectively inhibit succinate dehydrogenase in parasite's muscle so as to stop the reduction of succinic acid from fumaric acid. Therefore the parasite's muscle metabolism lacks of oxygen and leads to decreasing of energy.
Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging.
Functions:
Levamisole is absorbed through the gut, can also be absorbed through the skin and is distributed throughout the body. It affects the neurotransmitters within the parasite and paralyzes the worm. The fish then passes the inactive worms. Good gravel vacuuming is advised after treatment to remove the paralyzed worms. It is not ovicidal, which means it will not affect eggs already present, but it will affect the larval stage of the worm. To ensure complete eradication of the parasite treat again after remaining eggs have hatched.
Usage:
Levamisole HCI is also a good alternative in cases of benzimidazole resistance. Levamisole Hydrochloride (Levamisole HCl), is an anthelmintic (animals roundworm, hookworm, etc.) agent commonly used in large livestock such as cattle, pigs and sheep.
It can selectively inhibit succinate dehydrogenase in parasite's muscle so as to stop the reduction of succinic acid from fumaric acid. Therefore the parasite's muscle metabolism lacks of oxygen and leads to decreasing of energy.
Application:
1) It is an anthelmintic (anti-worm) agent commonly used in large livestock such as cattle, pigs and sheep.
2) Levamisole Hydrochloride is used in humans for diseases related to imbalances in the regulation of immune responses or deficiencies of the immune system, including autoimmune diseases, chronic and recurrent diseases, chronic infections and cancer.
3) It has beneficial effects on host defense mechanisms and restores depressed immune responses in animals and humans. Another interesting use of levamisole in humans is as a treatment for common warts (verruca vulgaris).
4) It can be used as pharmaceutical raw materials, as an anthelmintic for the treatment of animals roundworm, hookworm, etc.
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