Pharamceutical product Isotretinoin for skin care
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Product name: Isotretinoin
CAS. NO.: 4759-48-2
Chemical Name: 3, 7-dimethly-9-(2, 6-trimethly-1-cylohexane)-2, 4, 6, 8-pelartetaenoic acid
Character: Yellow crystals, trans tretionoirum mainly. Easily dissolved in chloroform, dichoromethane and dissolved in carbinol, ethanol and also dissolved in vegetable oil and lipid. Instability exposed in light and caloricr, easily absorbing moisture and metamorphosed in water.
Quality Index: Conform CP2005/BP2002/USP26
Melting Point: About 182 centigrade
Loss on Drying: ≤0.5%
Heavy Metals: ≤0.002%
Isotretinoin is a medication used for the treatment of severe acne. It is sometimes used in prevention of certain skin cancers. It is a retinoid, meaning it derives from vitamin A and is found in small quantities naturally in the body. Isotretinoin binds to and activates nuclear retinoic acid receptors (RAR), thereby regulating cell proliferation and differentiation. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
As the retinoid, there are strong and fast proliferation inhibition and differentiation of skin gland cell function, effective on severe nodular cystic acne. The gastrointestinal absorption is better, while the local medication invalid. Other drugs used to treat invalid serious acne, cystic acne, acne conglobata, rosacea, ichthyosis, keratosis follicularis and pityriasis rubra pilaris and other skin diseases also have a certain effect. For severe acne. Anti skin dyskeratosis medicine. For the treatment of severe acne and other disorders. Belong to whitening prohormones, can made INTO injections! Works very well in whitening!
What is the usual dose of isotretinoin?
The range of doses used each day for acne is less than 0.1 to over 1 mg/kg body weight. Some patients may only need a small dose once or twice a week. A course of treatment may be completed in a few months or continue for several years. For acne, some prescribers have targeted a total cumulative dose of 120-140 mg/kg, in the hope of reducing relapse, but the evidence for this remains controversial. The general trend has been to use lower dosages, unrelated to body weight (eg 10 mg/day).
How to Use Isotretinoin:
Read the Medication Guide provided by your pharmacist before you start using isotretinoin and each time you get a refill. Read and sign a Patient Information/Informed Consent form before you start taking this medication. If you have any questions about isotretinoin, consult your doctor or pharmacist before taking the medication.
Swallow capsules whole. Do not crush or chew them. Isotretinoin is usually taken twice daily for 15-20 weeks, or as directed by your doctor. Directions for most generic forms of isotretinoin state that it should be taken with meals. However, the FDA has indicated that the Absorica brand may be taken with or without food. Food helps increase absorption of this drug into your bloodstream. Ask your doctor or pharmacist for more information. Take this drug with a full glass of water, and do not lie down for 10 minutes after taking it.
The dosage is based on your medical condition, weight, and response to treatment.
Your acne may worsen during the first few days of taking this drug, and it may take up to 1-2 months before you notice the full benefit of this medication. If severe acne returns, a second course of treatment may be started after you have stopped taking the drug for 2 months. The manufacturer does not recommend long-term use of isotretinoin. Do not take more than the recommended dose.
Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.
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