Isotretinoin CAS.4759-48-2

Isotretinoin CAS.4759-48-2

We also formulate isotretinoin – an effective drug used in treatment of severe recalcitrant nodular acne. We follow an innovative micronized formulation of isotretinoin which is also clinically equivalent to standard isotretinoin with improved bio availability and minimal food effect.

Product Details

Isotretinoin Accutane Acne Treatment Skin

Foshan Xinhang Biological Technology Co., Ltd.

Whatsapp:+8617725670492, email:liuxf@yccreate.com.

Key words:S-23 ,Selective Androgen Receptor Modulator,S.A.R.M.S,


1.Product Introduction

Welcome to contact Morgan for more details.Whatsapp:+8617725670492, email:liuxf@yccreate.com.


We also formulate isotretinoin – an effective drug used in treatment of severe recalcitrant nodular acne. We follow an innovative micronized formulation of isotretinoin which is also clinically equivalent to standard isotretinoin with improved bio availability and minimal food effect. The safety profile of the micronized formulation has not been described previously. Isotretinoin is a very effective medication for the treatment of acne.


2.Specifications:

Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments.Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.


It is also somewhat effective for hidradenitis suppurativa and some cases of severeacne rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoinhas been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.


Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this indication as there are more effective treatments. Isotretinoin may represent an efficacious and safe alternative systemic form oftherapy for recalcitrant condylomata acuminata (RCA) of the cervix. In most countries this therapy is currently unapproved and only used if other therapies failed.


3.Applications:

Isotretinoin also known as 13-cis-retinoic acid, is an oral pharmaceutical drug primarily used to treat severe nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.


This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). It belongs to a class of drugs known as retinoids. It works by decreasing facial oil (sebum) production. High amounts of sebum can lead to severe acne. If left untreated, severe acne may cause permanent scarring.


Caution: Do not use isotretinoin if you are pregnant, may become pregnant, or if you are planning to become pregnant. Serious and sometimes fatal birth defects can occur if isotretinoin is taken during pregnancy.


Isotretinoin 10 mg capsule
The dose of isotretinoin patients receive is dependent on their weight and the severity of the condition. High-dose treatments are administered between 0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 to 1 mg/kg/day, given as a single dose with food). Usually a course will last 8-10 months. A second course may be required. Efficacy appears to be related to the cumulative dose of isotretinoin taken, with a total cumulative dose over each course of 120-150 mg/kg used as a guideline.
Nearly all patients achieve initial clearing of acne during a normal course of isotretinoin therapy. 90% of patients achieve excellent clearance of their acne after a cumulative dose of 150 mg/kg.

Lower-dosage treatments, such as 10-20 mg/day (approximately half the high dosage treatments above), can also be effective, with greatly diminished side effects.However, such lower dosage courses may be associated with higher relapse rates, requiring additional courses, especially if not taken for enough time.

Usually, a starting dose of 20 mg is taken with the largest meal of the day. After a few months, the dose is increased, e.g., to 40 mg/d. If side-effects permit, a higher dose such as 60 mg/d can be prescribed although daily dose rarely exceeds 60 mg. If 20 mg capsules are supplied, patients may take (for example) 20 mg one day, then 40 mg the next to provide an average daily dose of 30 mg/d. In most cases, isotretinoin achieves a complete clearing of acne during a standard-dose 12-16 week course. Some patients' acne will respond to a course before recurring, needing multiple courses of treatment.


4.Prodection details

Isotretinoin


5.Product Qualification

Product name

Isotretinoin (13-cis Vitamin A acid)

CAS No.

4759-48-2

Packing100G/25KG


Date of manufacturing

20161111

Shelf life

20181111

Standard

USP34

ITEMS

SPECIFICATION

RESULTS

Appearance

Yellow or orange crystalline powder

Complies

Identification

Complies

Complies

Loss on drying

<0.5%

0.05%

Residue on ignition

<0.1%

0.02%

Heavy metals

<0.002%

<0.002

Tretinoin

<1.0%

0.1%

Assay

98%~102.0%

99.8%

Conclusion

Qualified


6.Delivery,shipping and serving

1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 25 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking code are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.


1) A system in accordance with GMP standard, supervision on whole production process.
2) Health Sources is equipped with advanced detecting device, such as AFS, GC, HPLC, UV etc, supply the detailed Certificate of Analysis.
3) Procurement-Strictly on selecting raw materials.
4) Production-Strictly according to the standard specifications, conform to USP, EP, BP, CP, AJI, FCC etc pharmaceutical and/or food standards.
5) Warehousing and storage: Clear and dry condition with suitable temperature.
6) Transportation - Audit and supervise the logistics environment to ensure storage safety.
7) Keep samples for all batches goods to be traceable in case of quality discrepance.


FAQ

Q1:Are you a manufacturer?

Our company is a leading manufacturer and we concentrates on trading as well. We have specialized in the development, production and sales of food and health care raw material for more than 10 years.


Q2:How to contact with us?
Click the Made in China "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours.

Q3:Which kind of payment terms do you accept?
For small order,you can pay by T/T or Western Union ,nomal order by T/T to our company account

Q4:Can you give me a discount price?
Surely,It depend on your quantity

Q5:How can i get a sample?
Free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from your order in the future.

Q6:How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.


Q7:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

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