Pharmaceutical Domperidone powder CAS:57808-66-9
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Domperidone Molecular formula:C22H24ClN5O2
Domperidone M W:425.91
Domperidone Appearance: White to off-white crystalline powder
Domperidone is a benzimidazole compound with strong gastric motility and antiemetic effects, can enhance the lower esophageal sphincter tension, prevent gastroesophageal reflux, enhance gastric motility and promote gastric emptying, coordination of the stomach and the fingers Intestinal movement, inhibition of nausea, vomiting, and effectively prevent bile reflux, does not affect gastric secretion. This product is a peripheral dopamine receptor antagonist, a direct block gastrointestinal dopamine receptors appear to promote gastric motility. Can enhance the esophageal motility and lower esophageal sphincter tension. Because of its poor penetration of the blood-brain barrier, it has almost no antagonistic effect on dopamine receptors in the brain and therefore can exclude mental and central nervous side effects
Nausea and vomiting
There is some evidence that domperidone has antiemetic activity.It is recommended in the Canadian Headache Society's guidelines for treatment of nausea associated with acute migraine.
Gastroparesis is a medical condition characterised by delayed emptying of the stomach when there is no mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication or a result of abdominal surgery. The condition causes nausea, vomiting, fullness after eating, early satiety (feeling full before the meal is finished), abdominal pain and bloating.
Domperidone may be useful in diabetic and idiopathic gastroparesis.
However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate (equate) well with relief of symptoms.
The uses or indications of domperidone vary between nations. For instance, in Italy it is used in the treatment of gastroesophageal reflux disease and in Canada, the drug is indicated in upper gastrointestinal motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents. A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
1). Domperidone is a kind of phenyl imidazole compounds with a strong role in promoting gastric motility and antiemetic effect. It can strengthen the tension of the sphincter of the lower part of the esophagus, preventing the stomach - esophageal reflux, enhancing the gastric motility, promoting the gastric emptying, coordinating the stomach and duodenal motility, suppressing nausea, vomiting, and effectively preventing the bile reflux without affecting the secretion of gastric juice.
2). This product is a kind of peripheral dopamine receptor antagonists which can directly block the gastrointestinal dopamine receptors and exhibit the stimulating effect of gastric motility. It can enhance the esophageal peristalsis and the tension of esophageal sphincter. Because of its poor penetration through the blood brain barrier, it has almost no antagonism against the dopamine receptor of the brain, and therefore can excluding the side effects of the spirit and the central nervous system.
3). A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
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