Dasatinib CAS 302962-49-8
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Dasatinib Basic Info
|PHYSICAL STATE||white crystalline powder|
|Usage||a selective tyrosine kinase receptor inhibitor|
|Storage||Store in cool and dry places, keep away from strong light|
|Package methods||hundreds of disgusied pacakges|
|After-sales service||Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.|
|Shipping method||FedEx,UPS,DHL,EMS, Fedex and so on, by air or sea.Will choose the best shipping way.|
|Delivery time||delivery quickly at the day when receive the payment, will be deliveried in 4-7days after tracking|
|Payment Methods||Western union, money gram, bitcoin and bank transfer|
Dasatinib, previously known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is an oral Bcr-Abl tyrosine kinase inhibitor (inhibits the "Philadelphia chromosome") and Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is being evaluated for use in numerous other cancers, including advanced prostate cancer.
BMS-354825 is an SRC family of protein tyrosine kinases for oral bioavailability of synthetic small molecule inhibitors. Dasatinib binds and inhibits the growth promoting activity of these kinases. Obviously, dacotinib has been shown to overcome the resistance of imidamidine to chronic myeloid leukemia (CML) cells containing mutations in the BCR-ABL kinase domain due to its low affinity for BCR-ABL kinase The SRC family of protein tyrosine kinases interact with a variety of cell surface receptors and participate in intracellular signal transduction pathways.
Dasatinib is commonly associated with transient elevations in serum aminotransferase levels during treatment, but with only rare instances of clinically apparent acute liver injury.
Based on modeling studies, dasatinib is predicted to bind to multiple conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines representing variants of imatinib mesylate sensitive and resistant disease.
Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression.
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1. Are you a manufacturer ?
Yes, We manufacture bulk products in our factory located in Jiayu, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan. But we also do some trading business
2. How to confirm the product quality before placing orders ?
a. We will offer you our products specification standard to you, and we test every batch of our product by HPLC, UV, GC and TLC and etc. We also cooperate with independent third party lab such as SGS,PONY etc.
b. Free samples of some products can be sent, only need to pay the shipping cost or arrange a courier to us and take the samples.
c. Send us your products specifications and requests, we will produce for you.
3. How to make order & payment ?
a. Proforma invoice will be sent after your confirmation of the order, or You can order from Alibaba ESCOW(SECURE PAYMENT), Trade Assurance
b. We can accept payment by T/T, Western Union, Escrow, ,Trade Assurance, L/C.
4. How to pack and storage ?
a. Packing: 1kg/Aluminum foil bag with Carton outside.
25kg/Fiber drum with double PE bags inside.
b. Storage: Store in cool & dry place, keep away from strong light and heat.
5. How to ship and delivery ?
a. Transit could be DHL,UPS,TNT, FEDEX, EMS. For mass orders, it will be delivered by air or sea.
b. Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.
6. Can I get a free sample?
Most sample is not free, the sample fees can be returned with order.
7. What about packing?
Packaging with aluminum foil bags, cardboard drums, iron drums, plastic drums, containers or packaging according to customer requirements.
8. What about shipping?
Shipping by express(FEDEX, EMS, DHL, TNT, USP, etc), by air or by sea.
How to place a order
1,Tell me the quantity and content you need,i will give you my offer.if the quantity is large,you will get a discount,or small gift.
2,When you agree with my offer.pay by Western Union;Money Gram;T/T or Bitcoin.
3,Send me your delivery information (name,address,phone number,etc.)
4,When we get the payment,i will arrange the delivery for you.
5,Within 1-2 days, packing pictures and tracking number will be send to you.
6,Every morning i will check the tracking information for you,until 4-7 days later you get your parcel.
7,If unlucky,it's delay by custom, we promise reship for you.(Although the probability of being detained almost does not exist)
8,When you get the parcel,anytime you have any question,we will help you.
If you have any further query,please feel free to contact me
whatsapp +8613302415760 email firstname.lastname@example.org