Azaperone CAS 1649-18-9

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

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Azaperone Quick Details



Product NameAzaperone
CAS1649-18-9
MOLECULAR FORMULAC19H22FN3O
MOLECULAR WEIGHT327.4
PURITY99.0%
EINECS216-715-8
PHYSICAL STATEwhite Crystalline powder
Usagea neuroleptic sedative, anti-anxiety depression
StorageSealed, light and oxygen resistant
Package methodsdrum or as your mind
After-sales serviceWarm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.
Shipping methodFedEx,UPS,DHL,EMS, Fedex and so on, by air or sea.Will choose the best shipping way.
Delivery timedelivery quickly at the day when receive the payment, will be deliveried in 4-7days after tracking
Payment MethodsWestern union, money gram, bitcoin and bank transfer

Azaperone Descrption


Azaperone is a neuroleptic sedative belonging to the butyrophenone class of pharmaceuticals. Butyrophenones work through the mechanism of central dopamine and peripheral adrenergic blockage to produce a strong anticholinergic effect. The other butyrophenone routinely used in wildlife is haloperidol as a longer acting tranquilizer.


Azaperone Application



Azaperone is most commonly used in combination with opiates and alpha-two agonists. In these combinations the dose is from 0.15 to 0.30 mg/kg body weight. If used alone the dose for sedation ranges from 0.5 to 2.0 mg/kg body weight depending on the species and desired level of effect. 

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression .


The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for anesthesia in combination with other drugs such as xylazine, tiletamine and zolazepam. Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals such as elephants. Use in horses is avoided as adverse reactions may occur.


New uses of azaperone in the United States are being found in light of its recent availability as a compounded pharmaceutical. Additional species, uses and doses are found in the Handbook of Wildlife Chemical Immobilization (Kreeger et al.)


Azaperone Dosage:

If used alone the dose for sedation is 0.5 to 2.0 mg/kg body weight depending on the species and desired level of effect. Uses and dose rates in combination with other drugs are found in

Recommended route of administration is deep intramuscular injection.
How supplied:

Azaperone was approved by the FDA in the 50 mg/ml concentration.
For use in swine it is compounded by ZooPharm in a concentration of 50 mg/ml.
Contraindications:

Animals showed reduced activity for about 6 hours post-induction with azaperone. It should not be used in game species 30 days prior to a legal hunting season. The effects of azaperone are NOT reversed with the narcotic or alpha-two reversal agents. Animals may exhibit extra pyramidal signs at the higher dose rates.


Azaperone Specification



Identification1) IRComplies

2) HPLCComplies
Water≤0.5%0.10%
Residue on Ignition≤0.2%0.08%
3) Residual solventsMethanol: ≤0.3%
Acetone: ≤0.5%
Ethanol: ≤0.5%
0.12%
0.01%
Not detected
Assay99.0~101.0% (calculated on anhydrous
and solvent free basis)
99.95%
ConclusionThe batch conforms to USP39 standard requirements


Azaperone powder

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