Pharmaceutcal Atropine sulfate powder CAS:51-55-8
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Name: Atropine sulfate
Melting point: 189-192 ° C (A)(lit. )
Specific rotation: -0.6 o (per USP 25 oC)
Sensibility: Light Sensitive
Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery.It is typically given intravenously or by injection into a muscle.Eye drops are also available which are used to treat uveitis and amblyopia.The intravenous solution usually begins working within a minute and lasts half an hour to an hour.Large doses may be required to treat poisonings.
(1) relaxation smooth muscle: This product has a lot of relaxation of the role of visceral smooth muscle, excessive activity or in the spasm of the smooth muscle was a significant relaxation, and the impact of normal activities of the smooth muscle less.
(2) inhibition of gland secretion: by blocking the M - cholinergic receptor inhibition of gland secretion. On the salivary glands and sweat glands of the most obvious inhibition. But also can lacrimal gland and respiratory gland secretion greatly reduced, but the impact of gastric acid secretion is smaller.
(3) the role of the eye: atropine by blocking the pupil sphincter and ciliary muscle M-choline receptors and the performance of mydriasis, increased intraocular pressure and paralysis. These three effects have important clinical significance.
(4) the role of cardiovascular: a larger dose (1 ~ 2mg) atropine can lift the vagus nerve inhibition of the heart, thus making heart rate. Large doses can expand the skin and visceral blood vessels, relieve small arterial spasm. The mechanism of dilation of blood vessels and the lifting of small vasospasm is unknown.
(5) excitement of the central nervous system: high doses of irritability, more words and delirium and so on. Poisoning dose (more than 10mg) can produce hallucinations, orientation disorders, involuntary movement and convulsions and so on.
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