Acitretin CAS.55079-83-9

Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Acitretin induce keratinocyte differentiation and reduce epidermal hyperplasia.

Product Details

Raw Materials Acitretin CAS 55079-83-9 For Soriasis

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1. Product Introduction:

Acitretin Product Name: Acitretin

Acitretin Alias: Acitretin, Etretin, Soriatane, Neotigason, Acitretine, Retinoid etretin, Acitretina, Acitretinum
Acitretin Synonyms: retinoidetretin
Acitretin CAS: 55079-83-9
Acitretin MF: C21H26O3
Acitretin MW: 326.43
Acitretin EINECS: 259-474-4
Acitretin MP: 228-230°C
Acitretin storage temp.: 2-8°C
Acitretin Chemical Properties Crystalline Solid
Acitretin Usage: A synthetic retinoid which is the major metabolite of etretinate (E938000).
Acitretin Purity: 98%
Acitretin Usage: API
Acitretin Package: 1KG foil bag; 25Kg drum


2. Product description:

Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Acitretin induce keratinocyte differentiation and reduce epidermal hyperplasia.


Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. Acitretin binds to nuclear receptors that regulate gene transcription.


First generation retinoid was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.


Acitretin (3)


3. Acitretin COA:

Product name

Acitretin

CAS No.

55079-83-9

Outer Packing

500G

Production date

2018-08-10

Shelf life

2021-08-09

Standard adopted

EP6.0.

Items of analysis

Specification

Results

Appearance

Yellow or greenish-yellow    crystalline powder

Yellow crystalline powder

Identification:
     First Identification B
     Second Identification A C

A) The specific absorbance    at the max is 1350 to 1475
     B) Sample IR spectrum must    match with that of standard
     C) Sample HPLC spectrum    must match with that of standard

Conforms

Conforms

Conforms

Solubility

Practically insoluble in    water, sparingly soluble in tetrahydrofuran. Slightly soluble in acetone and    in ethanol(96 percent). Very slightly soluble in cyclohexane.

Conforms

Loss on drying

≤0.5%

0.3%

Sulfated ash

≤0.1%

0.05%

Heavy metals

≤0.002%

< 0.002%

Palladium

≤0.001%

<0.001%

Related substances

Impurity A:≤0.3% Impurity B:≤0.3%

0.18%; 0.16%

Total impurity:

≤1.0%

0.40%

Assay (anhydrous)

98.0%-102.0%

99.9%

Conclusion

Qualified


4. Acitretin Application:

Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects, Acitretin is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments.


Acitretin binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.


Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.


5. Related Products:

Pharmaceutical Raw Materials

Product Name

CAS. NO.

1,4-butanediol(BDO)

110-63-4

Isotretinoin

4759-48-2

Pregabalin

148553-50-8

Ursodeoxycholic acid

128-13-2

Acitretin

55079-83-9

Prostaglandin E1

745-65-3

Tiletamine HCL

14176-50-2

4,4-Piperidinediol hydrochloride

40064-34-4

N-Methyl-4-piperidinol

106-52-5

N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3

Gamma-Butyrolactone(GBL)

96-48-0


6. Order Process:

-Know what would you need

-Send you total price and make shipping plan

-If you think ok and send payment

-We will ship the parcel in 12-24 hours and then send packing photo and tracking number to you

-We will keep tracking it and let you know the details

-Parcel will be delivered in 4-5 working days


7. The quality control process:

1)Purchasing

Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.


2) Inspection

Four steps: sampling, sample pretreatment, measuring and data processing.


3) Producing

a)Each operator must do self-inspection of products and make the corresponding inspection records.

b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.


4) Before selling

Test result can be provided before selling.

Third-party detection institution is allowed if you are not satisfied with test results.

Acitretin (4)

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