Acitretin CAS: 55079-83-9
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Keywords: Acitretin; CAS: 55079-83-9
1. Product Introduction
Product Name: Acitretin
CAS No.: 55079-83-9
Molecular formula: C21H26O3
Molecular weight: 326.43
Product Specifications: Pharmacopoeial grade
Purity: 99%+
Brand: Biocar
Origion: Hubei,China
2. Product description:
Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of acitretin. They induce keratinocyte differentiation and reduce epidermal hyperplasia.
Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription .
Acitretin was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days .
3. Acitretin COA
Item | Specification | Result |
Assay | 98%to102.0% | Conforms |
Organoleptic | ||
Appearance | White to Light Yellow Powder | Conforms |
Odor | Characteristic | Conforms |
Physical Charactristics | ||
Particle size | 100% Through 80 Mesh | Conforms |
Loss on Drying | <2.0% | 0.46% |
Heavy Metals | ||
Total Heavy Metals | ≤10ppm | Conforms |
Arsenic | ≤2ppm | Conforms |
Lead | ≤2ppm | Conforms |
Microbiological Tests | ||
Total Plate Count | ≤1000cfu/g | Conforms |
Total Yeast & Mold | ≤100cfu/g | Conforms |
Yeast&Mold | ≤100cfu/g | Conforms |
Salmonella | Negative | Negative |
E.Coli. | Negative | Negative |
4. Acitretin Applications:
Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments .
It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer .
Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects .
5. Related Products:
Glucocorticoid Steroid Powder | |
Product Name | CAS NO. |
Dexamethasone | CAS:20-02-2 |
Dexamethasone Sodium Phosphate | CAS:55203-24-2 |
Beclometasone | CAS:5534-09-8 |
Cortisone | CAS:53-06-5 |
Hydrocortisone | CAS:50-03-3 |
Prednisone Acetate | CAS:125-10-0 |
Fluticasone | CAS:948566-12-9 |
mometasone furoate | CAS:83919-23-7 |
Triamcinolone | CAS:76-25-5 |
Beclometasone Dipropionate | CAS:5534-09-8 |
6. Order Process:
7. The quality control process:
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
