Sunifiram CAS: 314728-85-3 Raw Powder
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Keywords: Sunifiram; DM-235; CAS: 314728-85-3
1. Product Introduction
Product Name: Sunifiram/ DM-235
Appearance: White powder
Shelf life: 2 years
Standard: In-house Standard
Usage: For the treatment of Alzheimers Dementia, Cognition Disorder, Neurologic Drugs, Senile Dementia, Acetylcholine Release Enhancers.
2. Product description:Sunifiram (DM-235) is a piperazine derived ampakine drug which acts as a positive allosteric modulator of AMPA receptors, and has nootropic effects in animal studies with significantly higher potency than piracetam. A number of related compounds are known, the best known being unifiram (DM-232).
This enhancement by sunifiram is associated with an increase inphosphorylation of AMPAR through activation of protein kinase II(CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCαactivation through Src kinase. Enhancement of PKCα activity triggers to potentiate hippocampal LTP through CaMKII activation. Sunifiram improves cognitive deficits via CaM kinase II andprotein kinase C activation.
3. Sunifiram COA:
|Assay(As Dried Base,%)||98.5% to 101%||99.68%||HPLC|
|Color||White to Colourless||Complies||Visual|
|Loss on Drying||≤1.0%||0.35%||USP|
|Residue on ignition||≤0.5%||0.08%||USP|
|Heavy metals (As Pb)||NMT20PPM||Conforms||USP|
|Related substance||Meet the requirements||Conforms||USP|
|Packing and Storage|
|Packing||Pack in paper-drums and two plastic-bags inside. 25kg/drum|
|Storage||Store in a well-closed container away from moisture and direct sunlight.|
|Shelf Life||3 years if sealed and stored properly.|
4. Sunifiram Benefits
Sunifiram increases energy levels, allowing users to feel more motivated and eliminate
Sunifiram increase Levels of concentration increase, and users feel less distracted by external stimuliSunifiram also enhances long-term potentiation, which is the forming of new connections regarding memory storage.
Sunifiram has some anxiolytic benefits. Feeling more relaxed is beneficial when trying to focus.
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