PRL-8-53 HCL powder for nootropoic products for brain improvement
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Other Names:Methyl 3-[2-[benzyl(methyl)amino]ethyl]benzoate hydrochloride
PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine (Benzylamine) that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.
Mechanism of actions of PRL-8-53:
How does PRL-8-5-3 work? The exact mode of action of PRL-8-53 remains not yet known. According to the Wikipedia introduction, PRL-8-53 does not display stimulant properties, and does not potentiate dextroamphetamine. It displays cholinergic properties, and potentiates dopamine while partially inhibiting serotonin. PRL-8-53 reverses the catatonic and ptotic effects of reserpine.
Dr. Hansl stated in his PRL-8-53 patent that PRL-8-53 functions through enhancing the response of the brain towards acetylcholine. If you want to know more about the detailed choline mechanism, you may read more information on our product page like alpha gpc, citicoline (CDP choline), etc. In his study, he suggested that it has cholinergic mechanisms. To some extent, it has been said to act as a dopamine agonist. It is also said to potentiate the release of dopamine whilst partially inhibit the release of serotonin - all of which helps in improving learning motivation among users.
PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.
Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
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