PRL-8-53 HCL Nootropic

PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%.

Product Details

1.Product Introduction

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Top Quality Prl-8-53 HCl hydrochloride Powder Nootropics CAS51352-87-5



PRL-8-53 HCL=PRL-8-53 hydrochloride

Chemical name:Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate
MW 319.82578


    PRL-8-53 stacks

    PRL-8-53 stacks with this compound paired with other supplements, drugs and minerals taken for different health goals and health conditions. Review the benefits, effects, side effects, and PRL-8-53 dosage as taken by other users. There are over 10 stacks in our database with PRL-8-53. Other names for this compound include Methyl 3-2-benzylmethylaminoethylbenzoate.

    PRL-8-53 HCL Dosage 
    The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.

    No adverse effects from a single 5 mg dose of PRL-8-53 were observed in the human study. Animal studies suggest that the compound has a high therapeutic threshold, but evidence is very limited because no comprehensive toxicity studies have been completed.

    PRL-8-53 powder’s Mechanism Of Action
    The mechanism of action for this nootropic is currently unknown but may, in part, lie with cholinergic mechanisms. Dr Hansl, the creator of the compound discusses in the Phi Delta Kappan journal that PRL-8-53 powder enhances brain’s the response to acetylcholine, and the compound is not a stimulant. The patent for PRL-8-53 raw powder mentions cholinergic mechanisms.

    An animal test involving rodents showed 4mg/KG increased apomorphine (dopamine agonist) increased compulsive gnawing in rats, suggesting that PRL-8-53 raw powder to some extent is a dopamine agonist . The same study noted an improvement in conditioned avoidance learning. This nootropic does not enhance amphetamine’s actions in rats and doesn’t appear inhibit MAO activity.The single study in humans briefly mentions that PRL-8-53 raw powder potentiates dopamine release and causes partial inhibition of serotonin.


    The single published study for PRL-8-53 shows a slight improvement of word acquisition during a memorization task. Participants were given 5mg of PRL-8-53 2 hours prior to testing and then were then asked to listen to a recording of 12 words in a particular sequence and recite them at future time points (shortly after testing, a day after and 4 days after). Minor benefits were found for immediate acquisition, but an over 80% improvement was noted for people tested later on who had initially scored poorly for the test (6/12 words correctly or below) .

    Mental Arithmetic Exercise:

    In the same article, Dr Hansl mentions a number based cognitive exercise where participants had to subtract 7, add 1, subtract 7, add 2 and so on until a "goal" number was reached. Shorter times to the "goal" number were noted in the PRL-8-53 group.

    Verbal Fluency Test:

    Dr Hansl discusses a test where subjects were asked to form words from a series of letters and dots. For example "U.R." had to be turned into any word by adding letters at the start and end of the word, while replacing the dots with a letter. "U.R." could be "current" for example. A statistically significant improvement was found in participants who had taken the drug.

    PRL-8-53 HCL Dosage

    The single published human study used 5mg of PRL-8-53 and found it enhanced recall on a word-remembering test. The patent for the compound mentions an oral dose of 0.01mg/kg per dose, taken 3 times per day.

    4.prodection details

    Items of analysis




    White or white crystalline powder



    Conform with NMR


    Melting point



    Loss on drying



    Residue on ignition






    Heavy metals

    NMT 20PPM


    5. Packaging & Deliveryraw_fat_loss_powders_lorcaserin_hydrochloride_hemihydrate_

    1.Packages are generally dispatched within 24 hours after payment

    2.After shipping we will provide: tracking number;pictures with your parcel;

    3.Shipping Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc.

    4.Air transport for large quantity

    5.Shipping time:Most countries can arrived within 3-10 days door to door

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