Nootropoic NSI-189 Powder

NSI-189 is a novel neurogenic compound independent of monoamine reuptake pathways. This trial evaluated oral NSI-189 as monotherapy in major depressive disorder. Any needs contact:whatsapp:+8613378646535 emails:eleven11@chembj.com

Product Details

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                    Nootropoic NSI-189  raw powder for  brain improvement 

Any needs contact :

whatsapp:+8613378646535

emails:eleven11@chembj.com


Product Name:NSI-189

Synonyms:NSI-189

CAS:1270138-40-3

MF:C22H30N4O

MW:366.4998

Product Categories:Inhibitors;Health care products additives

Purity:99%

Appearance: White powders

Package: 200g/foil bag

Grade: pharmaceutical grade

Field: Small molecule inhibitors

Usage: Health care products additives. Ib clinical trial for major depressive disorder (MDD).


Description:


NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).



Product Applications:


1) Enhance cognition and memory formation.

2) Anxiolytic properties.

3) Anti-depressive effect .

4) Treatment of Alzheimer's and Parkinson's disease.

5) Increase coordination.

6) Improves mood.

7) Help fight fatigue.

8) Prevent oxidation within the brain.

9) Treat alcohol related brain damage.


How NSI-189 works:


This drug was developed to address three important aspects of depression including hippocampal volume, neurogenesis and neurotransmission. NSI-189 increases the volume within the hippocampus. In so doing, hippocampal volume and healthy brain cell density is increased thereby improving mod and cognitive performance. Aside from increasing hippocampal volume, the drug also improves neuronal cell functionality. It works it promoting healthy neuronal cell growth whilst repair damaged areas in the brain.


Benefits:


Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 . The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ) .


Dosage and Suggestion:


Studies conducted to evaluate effects of NSI-189 revealed that 40 to 80 mg daily is effective in treating depression and cognitive symptoms amongst healthy patients. In these trials, there are no serious adverse events recorded.

Generally, NSI-189 is well tolerated and safe for human use.


Our advantages:


Over 15years specialized in this field,Professional & Experienced sevices provided.

1. Best prices with High quality.We have complete QA&QC system;steroid powder purity is more than 99% hplc. We use the right recipe to cook the injectable steroid oil. All our order will send out after passing the test exam.

2. Rich experienced in delivering the parcels to you.The most disguise package and the most professional shipping company to ensure safe delivery. .

3. Enough stock ensure the prompt delivery time.

4. Good after-sales service.

5. Specials are possible when the order is big enough.

6. The most important thing is that we have resend policy to protect you 100%.


Packaging & Delivery:

We have professional team for package and shipment. Special way to ship 100 grams to 100kg powders at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed


Any needs contact :

whatsapp:+8613378646535

emails:eleven11@chembj.com


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