Galantamine HCL CAS. 357-70-0

Galanthamine is a kind of anticholinesterase drug, which can better improve the conduction between nerve and muscle. it could be used myasthenia gravis, progressive myodystrophy, post polio syndrome, child brain paralysis, sense obstruction, cinesipathy and polyneuritis induced by nervous system diseases.

Product Details

Nootropic Raw Material Galantamine Hydrobromide CAS 1953-04-4

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Quick Details

Galanthamine is a kind of anticholinesterase drug, which can better improve the conduction between nerve and muscle. it could be used myasthenia gravis, progressive myodystrophy, post polio syndrome, child brain paralysis, sense obstruction, cinesipathy and polyneuritis induced by nervous system diseases.


Product Name

Galantamine Hydrobromide

Alias

Galantamine hbr

CAS

1953-4-4

MF

C17H22BrNO3

MW

368.27

EINECS

217-780-5

Purity

99.50%

Grade

Pharmaceutical Grade

Appearance

white crystalline powder

Standard

USP30

Stock

Mass Stock

Packing Methods

designed disguised packing ways, 100% pass custom guarantee

Delivery time

within 18 hours after payment confirmed

Payment

T/T, Western Union,Money Gram , Bitcoin

Usage

Usage A selective acetylcholinesterase inhibitor. A therapeutic agent for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism. anticholinesterase, analgesic, anti Alzheimer


Application:

1. Galanthamine is alkaloid which is extracted from Amaryllidaceae plants Lycoris squamigera Maxim or Lycoris aurea,it is a reversible anti-cholinesterase drug, it is easy for it to go through the blood brain barrier into the brain tissue ,its effect on central nervous system is stronger.


2. it can improve neuromuscular conduction,compared with physostigmine, neostigmine,pyridostigmine, it has wide range of treatment, and low toxicity, muscarinic effects are weak and short-lived. Clinically Galanthamine is used not only for the treatment of myasthenia gravis, polio sequelae resting, but also for children with cerebral palsy, multiple neuritis, radiculitis and sensorimotor disorders caused by nervous system disease or trauma .


Galantamine Hydrobromine(4)


Specification:

Items of analysis

Specification

Results

Appearence

White crystalline powder

White crystalline powder

Identification

IR HPLC

Complies

Test for Bromide

A yellow precipitate is formed indicating the presence of bromideions.

Complies

Loss on Drying (%w/w,determined on 1.0g)

Not more than 0.5%

0.25%

Residue on Ignition (%w/w,determined on 1.0g)

Not more than 0.1%

0.06%

Solubility

Soluble in 0.1N sodium hydroxide, sparingly soluble in water, very slightly

Complies

Heavy metals

Not more than 20 PPM

Less than 20 PPM

Limit Of Galanthamine Enantiomer [(+)-Galanthamine] (By HPLC,%w/w)

Not more than 0.01%

Not detected

Norgalanthamine [USP:N-Desmethylgalantamine]

Not more than 0.20%

Not detected

Lycoramine[USP:Dihydrogalantamine]

Not more than 0.35%

0.13%

Glanthamine N-oxide

Not more than 0.20%

Below Limit of Quantification

Epigalanthamine

Not more than 0.40%

Below Limit of Quantification

O-Desmethylgalanthamine

Not more than 0.20%

Not detected

Narwedine

Not more than 0.15%

0.02%

Any other

Not more than 0.10%

Not detected

Total

Not more than 1.0%

0.17%

Assay

98.0-102.0%

99.77%

Toluene

Not more than 890 ppm

Below Limit of Quantification

Ethanol

Not more than 5000 ppm

377ppm

Tetrahydrofuran

Not more than 500 ppm

Not detected

Bromide Content

Between 20.6 %and 22.8%

21.70%

Particle Size(By Malvern Particle size analyzer, µm)

D(v,0.1)

29 µm

Conculsion

The results can conform to USP30 Standard


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