Donepezil CAS No.: 120014-06-4 Raw Powder

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Keywords: Donepezil, CAS No.: 120014-06-4

1. Product Introduction

Product Name: Donepezil

CAS No.: 120014-06-4

Molecular formula: C24H29NO3
Molecular weight: 379.49
EINECS number: 601-651-9
Melting point : 207 ° C
Water solubility : 2.931 mg/L
Uses: Donepezil hydrochloride-water is a centrally reversible acetylcholinesterase inhibitor.
Dangerous goods mark : Xi
Customs code: 29333990

Donepezil (1)

2. Product description:

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

Donepezil has been tested in other cognitive disorders (and is sometimes used off label) including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia. Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

3. Donepezil COA:

TEST ITEM	SPECIFICATION	RESULT
Appearance	Off white to white crystalline powder	Complies
Solubility	freely Freely soluble in chloroform, soluble in water and Acetic acid, slightly soluble in Acetonitrile and ethanol, insoluble in Ethylacetoacetate and n-hexane	Complies
Identification	(1)By IR absorption ,To match with working standard	Complies
	(2) The retention time of the major peak of the sample should accord with that of the working standard.	Complies
	(3) Test for chlorides. Reponds to the test for Chlorides.	Complies
PH	4.0-7.0	6.10
Residue on ignition	≤0.1%	0.03%
Related substance	Any Unkonwn single impurity≤0.3% Total ≤0.5%	0.04% 0.18%
Heavy metal	≤10ppm	<10ppm
Residual Solvents	Methanol≤0.3% Ethanol≤0.5% Ethyl acetate≤0.5% Toluene≤0.089% Acetic acid≤0.5%	Not detected Not detected Not detected Not detected Not detected
Loss on drying	≤0.5%	0.20%
Assay	On dried base, C24H29NO3·HCl should be 98.0% to 102.0%	100.20%
Conclusion: The product complies to Enterprise standard

4. Donepezil Benefits

(1) Donepezil binds and inactivates reversibly the cholinesterases, thus inhibiting hydrolysis of acetylcholine. This results in an increased acetylcholine concentrations at cholinergic synapses.
(2) The precise mechanism of action of donepezil in patients with Alzheimer's disease is not fully understood. Certainly Alzheimer's disease involves a substantial loss of the elements of the cholinergic system and it is generally accepted that the symptoms of Alzheimer's disease are related to this cholinergic deficit, particularly in the cerebral cortex and other areas of the brain.

(3) It is noted that the hippocampal formation plays an important role in the processes of control of attention, memory and learning. Just the severity of the loss of cholinergic neurons of the central nervous system (CNS) has been found to correlate with the severity of cognitive impairment.

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