Tetracaine Powder

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

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Tetracaine Quick Details


Tetracaine is a topical opththalmic anesthetic used to relieve the pain the skin and as an eye drops for minor eye operations. It prevents voltage-sensitive release of Ca2+ from sarcoplasmic reticulum and can be used as a spinal anesthetic.


Product NameTetracaine
AliasAnetain, Amethocaine, Pontocaine,Ametop,Dicaine
CAS94-24-6
MOLECULAR FORMULAC15H24N2O2
MOLECULAR WEIGHT264.36
PURITY≥99% 
EINECS202-316-6
PHYSICAL STATEWhite Lyophilized Powder
UsageTetracaine is a prescription medication used to prevent pain and induce anesthesia.
Package methodshundreds of stealth packages
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Tetracaine Application 


(1) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.


(2) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent  hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.


(3) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.


Tetracaine Dosage:


Tetracaine is given as an injection through a needle placed into an area of your middle or lower back near your spine. You will receive this injection in a hospital setting.


Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving tetracaine injection.


Spinal numbing medicines can have long-lasting effects on certain body processes such as sexual function, bowel or bladder control, and movement or feeling in your legs or feet. Talk with your doctor about these effects.


Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.


Since tetracaine is given as needed before a surgery or other medical procedure, you are not likely to be on a dosing schedule.


Tetracaine raw


Tetracaine Specification


Test ItemsSpecificationTest Results
AppearanceFine, white, crystalline, odorless powderconfirm
IdentificationABC in Passconfirm
SolubilityVery soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene
confirm
USP Reference standardsUSP Tetracaine Hydrochloride RS
USP Endotoxin RS.
confirm
Melting point145~150 degree146.0~147.5 degree
Chromatographic purityIn Passconfirm
Related substanceNot more than the reference solution 0.05%confirm
Heavy metals≤10ppmconfirm
PH4.5-6.55.8
Residue on ignition≤0.10%0.05%
Loss on Drying≤ 0.5%0.19%
Assay98.0 -101.0%100.1%


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4Tetracaine HCl136-47-0
5Benzocaine Hydrochloride23239-88-5
6Benzocaine94-09-7
7Aarticaine HCl23964-57-0
8Prilocaine721-50-6
9Prilocaine HCl1786-81-8
10Levobupivacaine HCl27262-48-2
11Ropivacaine HCl132112-35-7
12Ropivacaine Mesylate854056-07-8
13Dyclonine HCl536-43-6
14Mepivacaine HCl1722-62-9
15Chloroprocaine HCl3858-89-7
16Dimethocaine94-15-5
17Tetracaine94-24-6

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Tetracaine powder
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