Tetracaine HCl Pain killer Powder
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Keywords: Tetracaine, pontocaine hydrochloride, anestaron, Tetracaine Hydrochloride
1. Product Introduction
Product Name: Tetracaine Hydrochloride
Synonyms: Tetracaine HCl; Amethocaine hydrochloride; Anethaine; Butethanol; Curtacain; Decicain; Gingicain M; Menonasal; Pantocaine; Pontocaine hydrochloride; Tetracaine hydrochloride; Tonexol
2. Product description:
Tetracaine hydrochloride generic names are tetracaine hydrochloride and amethocaine hydrochloride. Its trade names are pontocaine hydrochloride and anestaron. It is a fine, crystalline, hygroscopic, odorless, powder which has a slightly bitter taste followed by a sense of numbness. Its molecular weight is 300.83. Attwood and Fletcher studied the self-association of tetracaine hydrochloride in water and electrolyte solutions using total intensity light scattering, photon correlation spectroscopy, and vapour pressure osmometry techniques. It melts at about 148°C, or it may occur in either of two polymeric forms, melting at about 134° and 139°C respectively; the mixture of the polymeric forms melts within the range 134° to I47°C. The x-ray powder diffraction data for tetracaine hydrochloride obtained on Norleco x-ray diffraction unit are given in this chapter. The FT-proton magnetic resonance (PMR) spectrum of tetracaine hydrochloride in heavy water obtained on Bruker (WM360) NMR spectrometer is also given in the chapter.
3. Tetracaine HCl COA:
| Items of analysis | Specification | Results |
| Description | A white,crystalline power | white,crystalline power |
| Identification | Easily soluble in water, soluble in ethanol, insoluble in ether and benzene | Complies |
| Identification | retention time consistent with the determination under | Complies |
| Identification | hould identify significant chloride reaction | Complies |
| Water | ≤2.0% | 0.23% |
| Melting range | About 148ºC | 148.8ºC~150.2ºC |
| Resiue on ignition | ≤0.1% | 0.034% |
| Related Substances | Complies | Complies |
| Ethanol | ≤0.5% | 0.055% |
| Acetone | ≤0.5% | Not detected |
| Methylbenzene | ≤.089% | Not detected |
| Assay | 98%~101.0% | 99.7% |
| Conclusion | Qualified |
4. Product Application:
For block anesthesia and epidural anesthesia.
Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
As painkillers of injection in the medicament.
Also used in suppository and ointment preparation, etc.
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