Pain Killer Pramoxine HCl Powder
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Keywords: Pramoxine HCl, Pramoxine Hydrochloride
1. Product Introduction
Product Name: Pramoxine Hydrochloride
English Synonyms: proctofoam; Pramoxine HCL; Praxomine Hydrochloride; Tronothane Hydrochloride; ; pramocaine Hydrochloride;
CAS: 637-58-1
EINECS Number: 211-293-1
Formula: C17H28ClNO3
MW: 329.8621
Boiling point: 427 ° C at 760 mmHg
Flash Point: 123.5 ° C
Vapor Pressure: 1.7E-07mmHg at 25 ° C
Assay:99.5%
Appearance: white or almost white crystalline powder
Uses:Local anesthetics
2. Product description:
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic
discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n
butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development,
pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially
good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and
subacute toxicity, well tolerated bymost mucous membranes and of a low sensitizing index in man. Like
other local anesthetics,paramoxine decreases the permeability of neuronal membranes to sodium ions,
blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable
neural membranes is thus inhibited, leading to numbness.
3. Pramoxine HCl COA:
| Items of analysis | specification | results |
| Appearance | white to almost white,crystalline | white,crystalline powder |
| Solubility | Freely soluble in water and in alcohol ,soluble in chloroform,very slightly soluble in ether | Complies |
| PH | About 4.5 | 4.63 |
| IdentifIcation | IR,HPLC,IdentifIcation | Complies |
| Melting point | 170ºC~174ºC | 171.7.ºC~172.7ºC |
| Residue on ignition | ≤0.1% | 0.02% |
| Loss on drying | ≤1.0% | 0.53% |
| Ethyl acetate | ≤0.089% | Not detected |
| Ethanol | ≤0.5% | 0.03% |
| Petroleum ether | ≤0.5% | 0.01% |
| Triethylamine | ≤0.5% | Not detected |
| Isopropanol | ≤0.5% | Not detected |
| Assay | 98.0%-102.0% | 99.99% |
| conclusion | qualified |
4. Pramoxine HCl Application:
1. Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or
other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and
scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
2. Muscle relaxant (smooth)and slows growth of unwanted facial hair.
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