Pain Killer Bupivacaine Powder
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1. Product Introduction
Product Name: Bupivacaine
Level: Pharmaceutical Grade
Appearance: white powder
Packing: 20KG only for export / full cardboard drum
Ingredients: 1-N-butyl-2-(2,6-dimethylcarbamoyl) piperidine
Physicochemical properties: White to almost white crystalline powder, easily soluble in dichloromethane, easily soluble in ethanol, ethyl acetate, almost insoluble in water
Category: Pharmaceutical Raw Materials
Field: Infiltration Anesthesia
Lower extension products: ointment.
Use: nerve conduction block anesthesia
2. Product description:
Bupivacaine is only found in individuals that have used or taken this drug. It is a widely used local anesthetic agent. [PubChem]Bupivacaine blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Bupivacaine binds to the intracellular portion of sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: pain, temperature, touch, proprioception, and skeletal muscle tone. The analgesic effects of Bupivicaine are thought to potentially be due to its binding to the prostaglandin E2 receptors, subtype EP1 (PGE2EP1), which inhibits the production of prostaglandins, thereby reducing fever, inflammation, and hyperalgesia.
3. Bupivacaine COA:
|Test Items||Specification||Test Results|
|Appearance||Fine, white, crystalline, odorless powder||confirm|
|Identification||A\B\C in Pass||confirm|
|Solubility||Very soluble in chloroform, soluble in Alcohol and Ether; insoluble in water||confirm|
|Melting point||106~110 degree||107.0~108.0 degree|
|Related substance||Not more than the reference solution 1.0%||0.40%|
|Heavy metals||≤ 10ppm||confirm|
|Residue on ignition||≤ 0.10%||0.05%|
|Loss on Drying||≤ 1.0%||0.20%|
|Assay||More Than 98.5 %||99.40%|
4. Bupivacaine Application:
Bupivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.
Bupivacaine is used as a local (in only one area) anesthetic.
Bupivacaine is given as an epidural injection into the spinal column to produce numbness during labor, surgery, or certain medical procedures.
Bupivacaine is also used as an anesthetic for dental procedures.
Bupivacaine may also be used for purposes not listed in this medication guide.
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