Pain Killer Bupivacaine HCl Powder
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Keywords: Bupivacaine Hcl, Bupivacaine Hydrochloride
1. Product Introduction
Product Name: Bupivacaine Hydrochloride
Alias: Bupivacaine Hcl
MF: C18H28N2O. ClH
Appearance: White Powder
Usage: Sodium channel blocker, local anesthetic.
2. Product description:
Bupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2, 6-dimethylphenyl)-, monohydrochloride, monohydrate, a white crystalline powder that is freely soluble in 95 percent ethanol, soluble in water, and slightly soluble in chloroform or acetone local or regional anesthesia or analgesia in surgical procedures (including oral surgery), diagnostic and therapeutic procedures, and obstetrical procedures use of the 0.75% solution of bupivacaine hydrochloride not recommended for obstetrical epidural anesthesia.
3. Bupivacaine HCl COA:
|Test Items||Standard||Test Results|
|Character||White crystalline powder||Conforms|
3. The aqueous layer responds to the tests for Chloride
|Heavy metal||Not more than 0.001%||Conforms|
|Residue on ignition||Not more than 0.1%||0.04%|
|Limit of residual solvents||Not more than 2%||Conforms|
|Conclusion||All analytical methods and results conform to the requirement of USP32.|
4. Bupivacaine HCl Application:
The aim is to administer the smallest effective dose. This varies with the procedure adopted, the degree of anaesthesia required, the rate of absorption from the injection site and the size and responsive-ness of the patient. Higher initial blood levels are attained with more concentrated solutions.
The maximum cumulative safe dose for adults and children of a 0.25% solution of bupivacaine is 1.5 mg/kg. The table provides a general guide to dosage in adults. Smaller dosages should be administered to debilitated, elderly, epileptic and acutely ill patients.
Bupivacaine is generally not recommended for children aged less than 12 years since there is insufficient information on the effects of its use in this age group.
Solutions containing preservatives should not be used for spinal, epidural or caudal anaesthesia.
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