Pain Killer Articaine HCl Powder
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Keywords: Articaine，Articaine HCl , Articaine Hydrochloride
1. Product Introduction
Product Name: Articaine HCl
Alias: Articaine hydrochloride
CAS NO.: 23964-57-0
Molecular Formula: C13H21ClN2O3S
Molecular Weight: 320.84
Appearance: White powder
Grade: Pharmaceutical Grade
2. Product description:
Articaine hydrochloride , its CAS NO. is 23964-57-0, the synonyms are 2-Thiophenecarboxylic acid,4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochloride ; 4-Methyl-3-(2-(propylamino)propionamido)-2 thiophenecarboxylic acid methyl ester HCl ; Articaine HCl ; Methyl4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride ; Septanest ; Septocaine .Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.
Structure and metabolism: The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.
3. Articaine HCl COA:
|Description||White or almost white powder||Conforms|
|Impurity D, G≤0.3%||Conforms|
|Impurity A,B,C, E, F, H, I≤0.2%||Conforms|
|Impurity with RRT 1.23≤0.2%||Conforms|
|Any other impurity≤0.1%||Conforms|
|Assay (by HPLC)||97.0~102%||99.05%|
|Conclusion||The results conform to EP6|
4. Articaine HCl Application:
Characteristic for articaine HCl is that they are fast acting and effective in penetrating bone. The latter has not been proven scientifically but is the opinion of those who work with these products. When using articaine HCl, the patient no longer has to return to the waiting room to allow the anesthetic to take effect. During treatment, it seems as though articaine HCl are more effective than most other anesthetics. For these reasons, increasing numbers of dentists and dental surgeons are opting for articaine HCl.
Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor.
The combination of articaine and adrenaline can be used for local or regional anaesthesia for dental procedures. Anaesthesia begins within six minutes and lasts for an hour. The half-life of articaine is approximately 1.8 hours. It is metabolised and then mainly excreted in the urine.
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