It can act on any part of the nervous system as well as various nerve fibers, affecting the sensory and motor nerves in its innervation. Since the effect is reversible, the nerve function can be completely restored after the end of the action, and there is no damage to the nerve fibers and cells.
Local anesthetic increases the excitation threshold of nerve fibers, slows the conduction velocity, reduces the amplitude of the action potential, and finally loses the ability to generate action potentials. Under the action of local anesthetics, pain sensation disappears first, followed by cold sensation, warm sensation, touch and pressure. The recovery of nerve impulse conduction proceeds in the reverse order.