Overview of local anesthetics

- Feb 01, 2019-

Local anesthetics (localanaesthetics) are a class of local reversible blocking of sensory nerve impulses that occur and transmit, referred to as "local anesthetics."


Local anesthetics (localanaesthetics) are a class of local reversible blocking of sensory nerve impulses that occur and transmit, referred to as "local anesthetics." In the case of keeping one awake, reversible causes the local tissue pain to disappear. In general, the action of the local anesthetic is limited to the site of administration and rapidly disappears as the drug spreads from the site of administration. The earliest applied local anesthetic was the alkaloid cocaine proposed from the coca leaf of South America, but its use was limited due to its high toxicity after absorption. In 1904, according to the chemical structure of cocaine, after the low toxicity of procaine was synthesized, the scope of use was continuously expanded. Lidocaine synthesized in 1943 is typical of amide local anesthetics.