Selank or selanc is a synthetic heptapeptide analog of the endogenous tetrapeptide tuftsin, with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. This synthetic variant of immunomodulatory tetrapeptide tuftsin possesses anxiolytic properties because of its mimic nature. Among this peptide's positive characteristics, are its ability to induce serotonin's metabolic processes and affect the concentration of specific monoamine neurotransmitters. Some scientists believe that Selank possesses such modulatory feature as influencing expression of brain-derived neurotropic factor.
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Selank is closely related to Semax, a hexapeptide previously invented by the same institute. Some consider Selank to be a more efficient alternative to Semax.
Selank as a Nootropic
Recreationally Selank is used to improve one's ability to focus and concentrate, reduce mental fatigue, increase mental sharpness and increase memory and learning capacity. The first noticeable effect is usually stabilization of mood and general feeling of well-being.
Selank as an Antiviral Agent
Selank neuropeptide also expresses immunomodulatory effects. In 2009 a study by F. Ershov et all. has evaluated antiviral properties of Selank both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2). The pronounced antiviral effect of Selank was detected in both systems. The highest efficiency - completely supressed viral reproduction was shown when Selank was added to the cell culture 24 hours before inoculation.
Improvement of learning and memory processes (reference, reference) Increased sensory attention Increased curiosity Increased mental clarity Restoration of balance of serotonergic and noradrenergic brain system activity (reference) Anti-anxiety - inhibition of anxiety (reference) Antiviral activity with no negative effects (reference) Psychostimulant, anti-asthenic - increased mental energy (reference) Stabilization of mood and overall feeling of wellbeing Reversal of anhedonia (restoring the feeling of pleasure) Potential restoration of catecholaminergic system functions after damage due to drug abuse reference.
In clinical trials, the drug has shown to provide a sustained nootropic and anxioytic effect, which is useful for the treatment of generalized anxiety disorder (GAD). Selank has an advantage over traditional anxiety treatments, as it has no sedating or cognitive side effects and no associated addiction or withdrawal syndrome. Selank also has very low toxicity with an overdose proving harmless even up to 500 times the effective dose. When released, the drug will be used as a 0.15% aqueous solution which is applied to the nasal mucosa in drops. It is thought that this is the best method for absorbing peptide based drugs. The drug can be used to suppress feelings of fear and anxiety in people with anxiety disorders and to stimulate learning and memory in healthy people.
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