Ipamorelin (or NNC 26-0161) belongs to regulatory peptides because it is GH releasing protein; Its chain is quite short and only consists of five amino acids. Its molecular mass/weight is 711.86 and its molecular formula is C38H49N9O5. Ipamorelin was synthesized as innovative and novelty mimetic of ghrelin therefore it possesses ability to enhance gastric motility. There are few ongoing clinical trials with ipamorelin at the current moment. The first studies on HGr-peptides including NNC 26-0161 started in early 1990s. Also this research compound is a selective secretagogue of G-hormone and ghrelin receptor's agonist. As other proteins ipamorelin reacts with GHRP-like receptors to release growth hormone from pituitary gland. But unlike few other peptides of hormones nature this pentapeptide doesn't release same volume of such compounds as cortisol and acetylcholine, and that makes it a very good candidate for future researches. Furthermore, NNC 26-0161 is more stable form of ghrelin and has longer half-life period, and it causes secondary effect by making neurons to become excited.
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Other name: L-Lysinamide,2-methylalanyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-D-phenylalanyl-;
Ipamorelin is an interesting peptide taken 300mcg twice daily or you could lower the dose for 3 times daily, side effects are head rushs.
I would recommend taking this 30 minutes before workout ,with gear, Ipamorelin is a new and potent synthetic pentapeptide which has distinct and specific hormone (GH)-releasing properties.
With the objective of investigating the effects on longitudinal bone growth rate , body weight , and GH release, Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was injected three times daily for 15 days to test subjects, After intravital Tetracycline
labelling on days 0, 6, and 13, LGR was determined by measuring the distance between the respective fluorescent bands in the proximal tibia metaphysis.
Ipamorelin is a 3rd generation GHRP behind GHRP-6 and GHRP-2. Ipamorelin has very similar characteristics of GHRP-2: does not have ghrelin's lipogenic properties and does not promote hunger. Ipamorelin acts synergistically when applied during a Growth Hormone Releasing Hormone (GHRH) pulse or when it is administered along with a GHRH or an analog such as Sermorelin or Modified GRF 1-29 (growth releasing factor, aminos 1-29).
The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH. On the other hand, Ipamorelin is similar to GHRP-6 because they both release GH at a very similar strength minus the side effects that of GHRP-6.
Both GHRP-6 and GHRP-2 cause a release and an increase in cortisol and prolactin levels, however Ipamorelin only selectively releases GH at any dose. Ipamorelin shares similar functionality to Hexarelin and compared to other peptides, it is a much more stable form of ghrelin and has longer half-life periods of at least two hours long and causes secondary effect by making neurons to become excited.
Ipamorelin dose-dependently increased LGR from 42 μm/day in the vehicle group to 44, 50, and 52 μm/day in the treatment groups .
Amino Acid Composition
±10% of theoretical
Water Content(Karl Fischer)
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