ACE-031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signaling via the ActRIIB receptor binding and increase muscle mass and strength. ACE-031 is a recombinant fusion protein that is artificially synthesized by fusion of standard antibody and a portion of ActRIIB receptor. The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.
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Some bodybuilders use ACE-031 to promote muscle growth and to improve lean muscle. No serious adverse events were reported after ACE-031. Most of the common adverse events are mild and tolerable. The polypeptide contains 368 amino acid molecules, which forms a very large polypeptide complex. Muscle growth is regulated by the production of amino acids , and TGF beta protein super family is mainly the regulator as indicated earlier the on and off switch mechanism is essential for muscle production. When ActRIIB receptors interact with the GDF-8, it sends an on signal, which in turn promotes muscle growth.
ACE 031 Effect
1. Fat loss and bone health
In the different studies conducted, the subjects experienced a decrease in leptin concentration and promoted adiponectin, which was a "good fat" hormone. So maybe Ace-031 does help to lose weight. Another study shows that the increase in alkaline phosphatase in blood and the reduction of collagen peptides; this may mean that it also helps to strengthen the bones.
2. Women weight loss
For overweight women were given a dose of 250 mg (mg) Ace 031. As a result, after one month, thigh muscle grew more than a pound. In addition, their lean weight increased by 3%, which is quite a result.
In the study with women, the concentration of FSH (follicle-stimulating hormone) decreased significantly and did not explain why. So there seems to be some side effects, we do not know whether men will happen the same thing. But we know that in the cattle, due to infertility, farmers refused to use Ace-031 "to strengthen" their stock.
ACE 031 Dosage
According to the bodybuilder who can get Ace-031, every 1-2 weeks, the dose seems to be between 1-3 mg per kilogram of body weight. $ 28 per milligram. In addition, taking into account the rough world of peptide companies, if you spend this money, you'd better make sure it was real product you are buying and no cheating so that you can get money back once you didn’t get anything from them.
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