Avanafil Powder CAS.330784-47-9

Avanafil is a selective inhibitor of phosphodiesterase type 5 (PDE5). It relaxes muscles of the blood vessels and increases blood flow to particular areas of the body. Avanafil is used to treat erectile dysfunction (impotence).

Product Details


1.Product Introduction

Welcome to contact Morgan for more details.Whatsapp:+8617725670492, email:liuxf@yccreate.com.


2.Specifications:


Product Name:Avanafil
Synonyms:(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide
CAS:330784-47-9
MF: C23H26ClN7O3
MW:483.95
Chemical Properties:White or off-white crystalline power
MP:150-152°C
Usage:Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.
Packing:As required


3.Applications:

 

In 16 separate 4-24 week trials of men (over 18 years old) who suffered from impotence for longer than 6 months, dosages between 10-200 mgs were administered. Significant improvements in erectile function, including frequency of penetration as well as erection duration post penetration, were reported with Sildenfil treatment compared to the placebo group.

Erections were improved in 72% of the Viagra group verses 18% of the placebo group. In all cases effects were dependant upon dosage and improvement was the greatest when dosage exceeded 100 mgs. Responses were decreased by 40-60% in patients suffering from diabetes and prostatectomy, respectively. Withdrawal rates were less than 5% related to negative side effects and limited response rates.



4.prodection details


COA of Avanafil:

ItemsSpecificationsResults
AppearanceWhite or off-white crystalline powerConforms
IdentificationIRConforms
SolubilityPractically insoluble in water and Slightly soluble in ethanolConforms
Melting point162-165°CConforms
Heavy metals≤10ppm2ppm
Loss on drying≤0.5%0.13%
Sulphated ash≤0.1%0.08%
Purity(HPLC)≥98%99.32%
Any other impurities≤0.5%0.26%
Total impurities≤2%0.55%

 



5. Packaging & Delivery


we have adequate stock,and can arranged within 24 hours when receive the payment.tracking number 
would be informed quickly after shipment.

we have special way could ship 2kg to 20tons products a time. we offer melting powder into liquid service
.and ship the liquid in special bottles.

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