Pharmaceutical Raw Materials Setipiprant CAS 866460-33-5 For Anti Hair Loss
Setipiprant Quick Details
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Setipiprant is an oral drug that’s currently being tested for use as a hair loss treatment. It was initially developed as a treatment for allergic rhinitis, but recent hair loss-related discoveries have made it a better candidate for hair loss reversal.
In short, setipiprant is an antagonist of the prostaglandin D2 receptor 2 (DP2). This receptor is responsible for bonding with and responding to certain prostaglandins, particularly PGD2. This prostaglandin has been linked to various pathological responses, including those linked to allergies, asthma, and inflammation.
As setipiprant is believed to interfere with the receptors known to contribute to allergies/allergic responses, the drug was first tested on allergies and asthma.
In clinical trials, the drug performed quite well in the treatment of allergen-induced airway responses in asthmatic patients. It was also well tolerated by participants. However, its results were similar to those of drugs already on the market, so further trials were discontinued.
According to researchers, setipiprant steps in before PGD2 attaches to the receptors, and therefore prevents receptor activation and, as a result, hair loss.
With the discovery of the possible link to PGD2 receptors, the drug was acquired by Kythera, and trials began to test the effects of setipiprant on hair loss.
How to Dose setipiprant
The experimental group will take 1000 mg setipiprant (two 500 mg tablets) twice daily at 12-hour intervals for a duration of 24 weeks.
The placebo group will take two placebo pills twice daily at 12-hour intervals for a duration of 24 weeks.
The study is quadruple masked, meaning the participants, care providers, investigators, and outcome assessors are blinded to which patients are within which group. This helps to keep results unbiased.
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